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CDKN1A — H2AFX
Text-mined interactions from Literome
Haug et al., Anticancer Res 2008
(Colonic Neoplasms) :
Growth inhibition, loss of clonogenicity, ataxia telangiectasia mutated (ATM) activation,
H2AX phosphorylation, TP53 stabilization,
CDKN1A induction , G2/M arrests, endoreduplication, negligible cell death and appearance of a senescence associated beta-galactosidase phenotype were observed
Tane et al., Cell cycle (Georgetown, Tex.) 2009
:
Moreover, the
gamma-H2AX focus formation was
suppressed by co-expressing
p21 ( Cip1/Waf1 ) or dominant negative Cdk2 mutant, suggesting that aberrant cyclin A-Cdk2 activation induces the chromosomal double-strand breaks
Wang et al., PloS one 2013
:
Stable expression of Lin28 and treatment with radiation
induced H2AX expression, while inhibited
p21 and ?-H2A.X