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BRAF — PIK3CA

Text-mined interactions from Literome

York et al., Mol Cell Biol 2000 : PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras, since both rapid ERK activation and the Ras dependent activation of the MAP kinase kinase kinase B-Raf are blocked by inhibition of either PI3-K or endocytosis
Wang et al., Ann Surg Oncol 2007 (Adenocarcinoma, Follicular...) : As to the three ATCs that had coexisted PTCs, mutated BRAF was detected in all PTC components but only in one ATC, while mutated PIK3CA was found in only one PTC component but not in the ATC
Steinestel et al., PloS one 2012 (Adenoma...) : Our results support a role for Abi1 as a downstream target of inflammatory response and adenomatous change as well as oncogenic KRAS mutation via PI3K , but not BRAF activation