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Ma et al., Immunol Cell Biol 2009
:
However, only IL-12 induced sustained expressions of CXCR5 and ICOS on these activated naïve CD4 ( + ) T cells, and endowed them with the ability to provide increased help to B cells for their differentiation into immunoglobulin secreting cells
McClymont et al., J Immunol 2011
(Diabetes Mellitus, Type 1) :
Naive Tregs were capable of upregulating expression of Th1 associated T-bet, CXCR3 , and IFN-? in response to IL-12