Frederickson et al., Mol Cell Biol 1992
:
The NGF induced enhancement of eIF-4E phosphorylation is abrogated in PC12 cells expressing a dominant inhibitory ras mutant ( Ser-17 replaced by Asn ), indicating that eIF-4E phosphorylation is dependent on a ras signalling pathway
Salehi et al., Mol Cell Biochem 2007
:
It is concluded that NGF regulates protein synthesis in the nervous tissue by enhancing expression and phosphorylation of eIF4E