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CEBPB — IRF6
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Cardinaux et al., Glia 2000
:
Here we show that
lipopolysaccharides (LPS) , IL-1beta, and TNFalpha
induce the expression of the
c/ebpbeta and -delta genes in mouse primary astrocytes
Gupta et al., Kidney Int 2000
:
To test the hypothesis that alpha-MSH inhibits the expression of inducible trans activating factors involved in NOS2 regulation, we used RAW 264.7 macrophage cells to examine the effects of alpha-MSH on the activation of nuclear factor-kappaB (NF-kappaB) and
CCAAT/enhancer binding protein-beta ( C/EBPbeta ), trans acting factors known to be
involved in
LPS + interferon (IFN)-gamma induction of the NOS2 gene
Liu et al., J Immunol 2003
:
Coimmunoprecipitation experiments in intact cells indicated that
LPS stimulated interaction between Sp1 and
C/EBPbeta and delta ... These results suggested that the interaction between Sp1 and
C/EBPbeta and delta
induced by
LPS cooperatively activated expression of the IL-10 gene
Kim et al., Biochem Biophys Res Commun 2005
:
8-Hydroxyquinoline inhibits iNOS expression and nitric oxide production by down regulating
LPS induced activity of NF-kappaB and
C/EBPbeta in Raw 264.7 cells
Tanaka et al., Am J Respir Cell Mol Biol 2005
:
STAT-1 and type I IFN receptor knockout mice have macrophages that are defective in IFN signaling, yet
LPS stimulation
induces inhibitory
C/EBPbeta , demonstrating that other cytokines can induce this repressor
Suh et al., Am J Respir Cell Mol Biol 2006
:
CO also decreased
LPS induced CCAAT/enhancer binding protein
(C/EBP) beta and delta protein expression in LPS treated RAW 264.7 cells
Cieslik et al., Mol Pharmacol 2006
:
We have reported previously that salicylate at 10 ( -5 ) M inhibited
LPS/IFNgamma induced
CCAAT/enhancer binding protein beta ( C/EBPbeta ) binding at 4 h but not at 8 or 24 h
Ejarque-Ortiz et al., Glia 2007
(Encephalitis...) :
The
LPS induced upregulation of glial
C/EBPbeta is rapid ( 2 h at mRNA level, 4 h at protein level ) ... The
LPS induced increase in microglial
C/EBPbeta is prevented by coadministration of the MAP kinase inhibitors SB203580 ( p38 inhibitor ) + SP600125 ( JNK inhibitor ) or SB203580 + U0126 ( ERK inhibitor )
Kobori et al., Br J Pharmacol 2007
(Adenocarcinoma...) :
Ergosterol peroxide and ergosterol suppressed
LPS induced DNA binding activity of NF-kappaB and
C/EBPbeta , and inhibited the phosphorylation of p38, JNK and ERK MAPKs
Djoko et al., J Agric Food Chem 2007
(Inflammation) :
In further, when these stilbenoids were subjected to monitoring their inhibitory effectiveness on
LPS induced transcription factor expressions of C/EBPdelta and
C/EBPbeta , only C/EBPdelta expressions were reduced
Eastman et al., Shock 1996
(Acute-Phase Reaction) :
Induction of hemopexin, alpha 1-acid glycoprotein, alpha 2-macroglobulin, GADD153,
C/EBP beta , and C/EBP delta mRNAs by
LPS were all abolished in dexamethasone treated rats
Goethe et al., J Leukoc Biol 1997
:
In this study, we describe the
LPS regulation of the
C/EBPbeta gene in myelomonocytic HD11 cells ... Nuclear run-on transcription experiments with isolated nuclei revealed that the rate of C/EBPbeta gene transcription was enhanced by LPS, demonstrating that the
C/EBPbeta gene in HD11 cells was regulated at the transcriptional level in
response to
LPS ... Furthermore, the
LPS induced binding activity of
C/EBPbeta to the -6.1-kb lysozyme enhancer was dependent not only on protein synthesis, but also on transcription
Adams et al., J Leukoc Biol 1997
:
As expected,
lipopolysaccharide (LPS) activated p65/p50 NF-kappaB and
C/EBP-beta NF-IL-6 complexes, increased the nuclear titer of p65 and p50 antigens, and increased cytokine ( IL-1beta, tumor necrosis factor alpha ) mRNA production