Gene interactions and pathways from curated databases and text-mining

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LEP — PCK1

Text-mined interactions from Literome

Anderwald et al., Mol Endocrinol 2002 : Leptin reduced L-lactate- ( 10 mmol/liter ) -stimulated glucose production by 39-66 % ( P < 0.006 vs. control ) and phosphoenolpyruvate carboxykinase ( PEPCK ) activity by 22-52 % ( P < 0.001 )
Gutiérrez-Juárez et al., J Biol Chem 2004 : Because melanocortin agonists also stimulate hepatic gluconeogenesis, here we examined whether central melanocortin blockade modifies the acute effects of leptin on GP, on gluconeogenesis, on glycogenolysis, and/or on the hepatic expression of the gluconeogenic enzymes glucose-6-phosphatase ( Glc-6-Pase ) and phosphoenolpyruvate carboxykinase ( PEPCK )
Jaubert et al., PloS one 2012 : Immunoprecipitation and western blot experiments showed that the leptin induced decrease in PEPCK-C level was correlated with an increase in PEPCK-C nitration