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PLAU — STAT3
Text-mined interactions from Literome
Dumler et al., J Biol Chem 1999
:
In this study, we demonstrate that Stat4 and Stat2, but not
Stat3 , Stat5, or Stat6, are rapidly activated in
response to
uPA
Shetty et al., Am J Physiol Lung Cell Mol Physiol 2006
:
uPA induced
Stat3-DNA binding activity in a time dependent manner ...
uPA induced
Stat3 activation does not require uPA catalytic activity, as the uPA amino-terminal fragment alone was as potent as active two-chain uPA ( tcuPA ) in causing this effect ... Single-chain
uPA likewise
induced tyrosine phosphorylation of
Stat3 to a similar extent as intact tcuPA ... Plasmin did not alter
uPA induced
Stat3 activation ... These results reveal for the first time that the
uPA-uPAR interaction
leads to activation of
Stat3 , independent of its catalytic activity but dependent on its interaction with its receptor, uPAR, leading to DNA synthesis in lung epithelial cells