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PKN2 — RAC1

Text-mined interactions from Literome

Bourguignon et al., J Biol Chem 2004 (Calcium Signaling) : Hyaluronan-CD44 interaction with Rac1 dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca ( 2+ ) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation ... The binding of HA to keratinocytes promotes PKNgamma kinase recruitment into a complex with CD44 and subsequently stimulates Rac1 mediated PKNgamma kinase activity
Bourguignon et al., J Neurochem 2007 : We determined that HA binding to astrocytes stimulated Rac1 dependent PKN gamma kinase activity which, in turn, up-regulated the phosphorylation of the cytoskeletal protein, cortactin, and attenuated the ability of cortactin to cross-link F-actin