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NA — SERPINE1
Text-mined interactions from Literome
Swiatkowska et al., Cell Mol Biol Lett 2002
:
Because TNFalpha induces
PAI-1 production in endothelial cells, and
NAC attenuated this response, we attempted to investigate the possible involvement of ROS in the activation of PAI-1 by TNFalpha ... Upregulation of
PAI-1 expression in endothelial cells by the stimulation with TNFalpha ( 50 ng/ml ) or H2O2 ( 10-200 micro M ), observed by measurement of the antigen and mRNA levels, was reversed in the
presence of
NAC ( 20mM )
Lee et al., Kidney Int 2005
(Diabetes Mellitus, Experimental...) :
NAC effectively
inhibited high glucose induced, but not basal,
PAI-1 expression
Chu et al., Surgery 2011
(Tissue Adhesions) :
The
effect of
NAC on tPA and
PAI-1 production was tested in vitro in human mesothelial cells