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AKT1 — CDK2

Text-mined interactions from Literome

Maddika et al., J Cell Sci 2008 : Akt mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis ... Here, we show that CDK2 , an S-phase cyclin dependent kinase, is a novel target for Akt during cell cycle progression and apoptosis ... Although CDK2 threonine 39 phosphorylation mediated by Akt enhances cyclin-A binding, it is dispensable for its basal binding and the kinase activity
Yin et al., Prostate 2009 (Prostatic Neoplasms) : In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2 , CDK4, and E2F and by activation of AKT
Villavicencio et al., Gynecol Oncol 2009 (Endometrial Hyperplasia...) : The PCOS condition is associated with increased Ser473-AKT phosphorylation, elevated expression of Ras, increased cytoplasmic abundance of p27, and increased nuclear abundance of CDK2 in the endometrial epithelial cells
Jia et al., PloS one 2012 (Metabolic Syndrome X...) : The activated Akt1 then increased the activity of CDK2 and accelerated the cell cycle progression of 3T3-L1 cells