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IRF6 — LY96

Text-mined interactions from Literome

Shuto et al., Biochem Biophys Res Commun 2005 : Membrane anchored CD14 is required for LPS induced TLR4 endocytosis in TLR4/MD-2/CD14 overexpressing CHO cells
Viriyakosol et al., Hybridoma (Larchmt) 2006 (Sepsis) : Eleven MAbs were characterized by enzyme linked immunosorbent assay ( ELISA ) with soluble TLR4/MD-2 complex (sTLR4/MD-2) and sMD-2, Western blotting against sMD-2 monomer and multimers, and inhibition of direct LPS binding to sMD-2
Kim et al., Cell 2007 : Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS
Steeghs et al., Infect Immun 2008 : The species-specific activation of the TLR4/MD-2 complex by LpxL1 LPS may have an impact on the use of LpxL1 LPS as an adjuvant and the use of murine immunization models in human meningococcal vaccine development
Tsukamoto et al., Int Immunol 2010 : We found that LPS induced TLR4/MD-2 dimerization occurred only in membrane associated CD14 (mCD14) expressing cells ... These studies suggest that LPS induced TLR4/MD-2 receptor dimerization is not essential for signaling but prompts rapid signaling during innate immune responses
Hsu et al., Cancer Res 2011 (Colorectal Neoplasms...) : Taken together, the results indicate that stimulation of the TLR4/MD2 complex by LPS activates PI3K/AKT signaling and promotes downstream ß1 integrin function, thereby increasing the adhesiveness and metastatic capacity of CRC cells
Ainge et al., J Med Chem 2011 : Furthermore, the interruption of the LPS induced 2 : 2 TLR4/MD-2 signaling complex formation by PIM ( 2 ) represents a previously unidentified mechanism involved in the bioactivity of PIM molecules