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IFNG — KLRC1
Text-mined interactions from Literome
Tieng et al., Proc Natl Acad Sci U S A 2002
(Crohn Disease) :
MICA induction on epithelial cells
triggered IFN-gamma release by the
NKG2D expressing natural killer cell line NKL
Derre et al., J Immunol 2002
(Melanoma) :
We show that IL-12 induces the expression of
NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was
mediated neither by
IFN-gamma nor by IL-15
Koike et al., J Exp Med 2004
:
Furthermore, anti-NKG2I mAb inhibited NK cell mediated cytotoxicity, whereas cross linking of
NKG2I enhanced interleukin 2- and interleukin 12-dependent
interferon-gamma production
Rincon-Orozco et al., J Immunol 2005
:
Furthermore,
NKG2D triggers the production of TNF-alpha but not of
IFN-gamma , as well as the release of cytolytic granules by Vgamma9 Vdelta2 T cells
Ortaldo et al., Blood 2006
:
Our studies demonstrate that cross linking of
NKG2D and NK1.1
results in a synergistic NK
IFN-gamma response when combined with IL-12 or IL-18
Nitahara et al., J Invest Dermatol 2006
:
Cross linking of
NKG2D on DETCs
induced IFN-gamma production
Girart et al., J Immunol 2007
(Melanoma) :
Engagement of TLR3, TLR7, and
NKG2D regulate
IFN-gamma secretion but not NKG2D mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12 ... Excitingly,
IFN-gamma secretion was significantly increased when NK cells were stimulated with poly ( I:C ) or loxoribine and IL-12, and
NKG2D engagement was
induced by coculture with MICA+ tumor cells in a PI3K dependent manner
Vahlne et al., Scand J Immunol 2008
:
A comparison of responses in naive mouse NK cells and NK cells pre activated with the type I interferon-inducer tilorone demonstrated a dramatic influence of pre-activation, allowing potent degranulation and
IFN-gamma responses to
NKG2D mediated stimulation that were not observed with naive NK cells
Wang et al., Mol Immunol 2008
:
NKG2D receptor-ligand interaction
triggers NK cell mediated cytolysis and
IFN-gamma secretion
Hidano et al., Int Immunol 2008
:
Although
NKG2D mediated
IFN-gamma production depends on phospholipase C (PLC) gamma 2, YAC-1 cell triggered IFN-gamma production is PLC gamma 2- and Syk/ZAP-70 independent and nuclear factor-kappa B mediated
Clayton et al., J Immunol 2008
(Mesothelioma...) :
Lymphocyte effector function was impaired by pretreatment with tumor exosomes, as these cells exhibited poor
NKG2D dependent production of
IFN-gamma and poor NKG2D dependent killing function
Schwinn et al., Int J Cancer 2009
(Glioma...) :
Here, we asked whether the proinflammatory cytokine
Interferon-gamma (IFN-gamma) affects
NKG2DL expression in melanoma
Fuertes et al., Medicina (B Aires) 2011
(Nevus...) :
Engagement of
NKG2D by MICA
triggers IFN-g secretion and cytotoxicity against malignant cells