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IFNG — PRKCA

Text-mined interactions from Literome

von Knethen et al., Antioxid Redox Signal 2005 : These results suggest that IFNgamma causes PC-PLC stimulation, diacylglycerol release, Ca2+ influx, and concomitant PKC alpha activation, which subsequently depletes PKC alpha
Hardy et al., Immunology 2009 : In addition, we showed that IFN-gamma induces the nuclear translocation of PKC-alpha but the mechanisms for this remain to be elucidated ... In this study, we sought to identify signalling pathways involved in IFN-gamma induced activation of PKC-alpha and to characterize their potential roles in modulating IFN-gamma induced responses in macrophages ... IFN-gamma mediated nuclear translocation of PKC-alpha was a Janus activated kinase 2 (JAK2) independent process, which required phosphatidylinositol 3-kinase (PI3K) and p38 mitogen activated protein kinase ( MAPK ) ... However, PKC-alpha phosphorylation was independent of PI3K and p38 MAPK, indicating that IFN-gamma induced phosphorylation and nuclear translocation of PKC-alpha are mediated by distinct mechanisms ... Taken together, our data indicate that PI3K and p38 MAPK modulate IFN-gamma stimulated PKC-alpha nuclear translocation independently of JAK2 activity and that both PI3K and PKC-alpha are required for type IV CIITA and MHC II gene expression in IFN-gamma stimulated macrophages
Ou et al., J Agric Food Chem 2009 : In conclusion, Ca2+ release and PKC-alpha activation are required for IFN-gamma production induced by FIP-fve in PBMCs