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EGFR — RHO
Text-mined interactions from Literome
Ohtsu et al., Arterioscler Thromb Vasc Biol 2005
(Cardiovascular Diseases) :
We have further demonstrated that the
Rho/ROCK activation by Ang II
requires protein kinase C-delta (PKCdelta) and proline-rich tyrosine kinase 2 (PYK2) activation, but not
epidermal growth factor receptor transactivation
Lin et al., Methods Enzymol 2006
:
The
Rho-family small G-protein, Cdc42, has been implicated in the
regulation of
EGFR degradation
Foltenyi et al., Nat Neurosci 2007
:
Our results demonstrate that
rhomboid (Rho)- and Star mediated activation of
EGFR and ERK signaling
increases sleep in a dose dependent manner, and that blockade of rhomboid ( rho ) expression in the nervous system decreases sleep
Samarakoon et al., J Mol Cell Cardiol 2008
:
Thus, two distinct pathways involving the
EGFR/pp60(c-src)/MEK-ERK pathway and
Rho/ROCK dependent SMAD2
activation are required for TGF-beta1 induced PAI-1 expression in VSMC
Yasugi et al., Development 2010
:
EGFR activation is
regulated by transient expression of
Rhomboid ( Rho ) , which is required for the maturation of the EGF ligand Spitz ...
Rho expression is also
regulated by the
EGFR signal
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012
:
In conclusion, PAR(2) activation drives COX-2 expression in Caco-2 cells via metalloproteinase dependent
EGFR transactivation and
activation of Src,
Rho , and PI3 kinase signaling
Jeong et al., Mol Oncol 2013
(Ovarian Neoplasms) :
Further we provide evidence that resveratrol inhibits
EGFR phosphorylation and subsequent
activation of a
Ras/Rho/ROCK signaling
Gohla et al., J Biol Chem 1998
:
Coexpression of
EGFR-CD533 and activated Galpha13 in COS-7 cells
resulted in decreased
Rho-GTP levels compared with expression of activated Galpha13 alone
Malliri et al., J Cell Biol 1998
:
Our data establish a novel link between AP-1 activity and
EGFR activation of Rac and
Rho , which in turn mediate the actin cytoskeletal rearrangements required for cell motility and invasion