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CD44 — MAP2K1

Text-mined interactions from Literome

Kobayashi et al., Int J Cancer 2002 (Bone Neoplasms...) : Our study indicates that ( i ) CD44 stimulation by fragmented HA upregulates expression of uPA and uPAR mRNA and protein but does not affect MMPs secretion or PAI-1 mRNA expression ; ( ii ) the effects of HA fragments are critically HA size dependent : high molecular weight HA is inactive, but lower molecular weight fragmented HA ( Mr 3.5 kDa ) is active ; ( iii ) cells can bind avidly Mr 3.5 kDa fragmented HA through a CD44 molecule, whereas cells do not effectively bind higher Mr HA ; ( iv ) a fragmented HA induces phosphorylation of MAP kinase proteins ( MEK1/2 , ERK1/2 and c-Jun ) within 30 min ; ( v ) CD44 is critical for the response ( activation of MAP kinase and upregulation of uPA and uPAR expression ) ; and ( vi ) cell invasion induced by CD44 stimulation with a fragmented HA is inhibited by anti-CD44 mAb, MAP kinase inhibitors, neutralizing anti-uPAR pAb, anti-catalytic anti-uPA mAb or amiloride
Judd et al., Cancer Res 2012 (Carcinoma, Squamous Cell...) : Conversely, MEK1 activation enhanced CD44 expression and promoter activity, whereas CD44 attenuation reduced in vitro migration and in vivo tumor formation