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INS — PKN2
Text-mined interactions from Literome
Dong et al., Proc Natl Acad Sci U S A 2000
:
Phosphorylation of
protein kinase N by phosphoinositide dependent protein kinase-1
mediates insulin signals to the actin cytoskeleton
Standaert et al., J Biol Chem 1998
:
Comparative
effects of GTPgammaS and
insulin on the activation of Rho, phosphatidylinositol 3-kinase, and
protein kinase N in rat adipocytes ... Whereas
insulin activated both
PKN and PKC-zeta, GTPgammaS activated PKN but not PKC-zeta ... Our findings suggest that ( a ) GTPgammaS and
insulin activate Rho, PI 3-kinase, and
PKN , albeit by different mechanisms ; ( b ) each of these signaling substances appears to be required for, and may contribute to, increases in glucose transport ; and ( c ) PKC-zeta may contribute to increases in glucose transport during insulin, but not GTPgammaS, action