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SHH — SLC22A3

Text-mined interactions from Literome

Maitah et al., PloS one 2011 (Carcinoma, Non-Small-Cell Lung...) : In this study we found for the first time that the induction of EMT by chronic exposure of A549 NSCLC cells to TGF-ß1 ( A549-M cells ) led to the up-regulation of sonic hedgehog (Shh) both at the mRNA and protein levels causing activation of hedgehog signaling
Xu et al., PloS one 2012 (Pancreatic Neoplasms) : The role of sonic hedgehog (SHH) in epithelial mesenchymal transition (EMT) of pancreatic cancer ( PC ) is known, however, its mechanism is unclear
Leask et al., Journal of cell communication and signaling 2013 : Sonic hedgehog (SHh) is responsible for PDAC cell proliferation, epithelial-mesenchymal transition (EMT) , maintenance of cancer stemness, migration, invasion, and metastatic growth ; in a recent report, it was shown that CCN1 is a potent regulator of SHh expression via Notch-1