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CTNNB1 — PPARD

Pathways - manually collected, often from reviews:

• BioCarta wnt signaling pathway: beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) → PPAR-delta (PPARD) (transcription, activates)
• NCI Pathway Database Presenilin action in Notch and Wnt signaling: beta catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 complex (CTNNB1-HNF1A-CTBP1-CREBBP-TLE1-AES) → PPAR delta (PPARD) (transcription, activates)

Text-mined interactions from Literome

Reed et al., Oncogene 2004 (Intestinal Neoplasms...) : Our data suggest that PPARdelta is not directly regulated by beta-catenin , and that inhibition of PPARdelta activity is unlikely to be an appropriate strategy for the chemoprevention or chemotherapy of intestinal malignancies
Han et al., J Cell Biochem 2008 (Cholangiocarcinoma) : Overexpression of PPARdelta or treatment with the selective PPARdelta ligand, GW501516, also increased beta-catenin binding to TCF/LEF response element and increased its reporter activity
Jeong et al., Cell cycle (Georgetown, Tex.) 2009 : In addition, PPARdelta increased protein kinase C ( PKC ), cytosolic phospholipase A ( 2 ) ( cPLA(2) ) and p38 mitogen activated protein kinase ( p38 MAPK ) phosphorylation, and Wnt/beta-catenin activation