◀ Back to CD28
CD28 — IL12A
Text-mined interactions from Literome
Cheung et al., Mol Immunol 1999
:
Thus ligation of
CD28 in the
presence of
IL-12 results in a synergistic increase in production of the cytokine
Chang et al., J Immunol 2000
(Encephalomyelitis, Autoimmune, Experimental) :
We demonstrate that IL-2 and
IL-12 resulting from
CD28/B7 interactions both play a critical role in the induction of expression of the IL-12Rbeta2 subunit and as a result the differentiation of pathogenic autoreactive effector cells
Kim et al., Blood 2002
:
The 4-1BB was induced preferentially on the CB CD28 ( - ) CD8 ( + ) T cells when
CD28 down-regulation was
induced by interleukin 15 (IL-15) and
IL-12 stimulation
Warrington et al., Blood 2003
:
Costimulation of the T-cell and
IL-12 receptors
induced the transcription of
CD28 in approximately 50 % of CD4 ( + ) CD28 ( null ) T-cell clones and lines ...
IL-12 by itself did not
restore CD28 expression
Ito et al., J Immunol 2003
(Encephalomyelitis, Autoimmune, Experimental) :
MOG-specific T cells stimulated with anti-CD3 and
anti-CD28 in the
presence of
IL-12 or IL-18 alone transferred only mild experimental autoimmune encephalomyelitis ( EAE ) into a low percentage of recipients
Ortega et al., J Leukoc Biol 2009
(Psoriasis) :
These cells are refractory to Tregs but show a proliferative response to
anti-CD3/CD28 stimulation that is
enhanced by
IL-12 and IL-15
DeKruyff et al., J Immunol 1997
:
IL-12 production in this T cell dependent system increased in direct proportion to Ag concentration and
required TCR ligation but not
CD28 costimulation
Monteleone et al., Gut 1998
(Colitis...) :
IL-12 did not induce proliferation of either unstimulated or preactivated T-LPLs and it did not
enhance the
CD2/CD28 stimulated T-LPL proliferative response
Ding et al., J Immunol 1998
:
Enhancement of costimulation by engagement of
CD28 only
resulted in augmentation of the capacity of the weak agonist APL to induce proliferation and IL-2/IL-3 production, but not CD40L or IL-12Rbeta2 chain expression on T cells, CD80/CD86 expression on APC,
IL-12 secretion, or IFN-gamma production