Gene interactions and pathways from curated databases and text-mining

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CD28 — IL21

Text-mined interactions from Literome

Okkenhaug et al., Nat Immunol 2001 : Nonetheless, this mutated form of CD28 still prevents the induction of anergy and promotes T cell proliferation, interleukin 2 secretion and B cell help
Abreu et al., Arthritis Res Ther 2010 (Arthritis, Experimental...) : Ex vivo, Rac1 inhibitory peptide suppressed T-cell receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help
Chen et al., Cytokine 2012 (Graft vs Host Disease) : Regulation of CD28 expression on umbilical cord blood and adult peripheral blood CD8+ T cells by interleukin(IL)-15/IL-21
Yu et al., Asian Pac J Trop Med 2013 (Melanoma) : Artificial antigen presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8 ( + ) CD28 ( + ) T lymphocyte responses