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IL6 — PRG2
Text-mined interactions from Literome
Guerne et al., Matrix Biol 1999
(Osteoarthritis) :
Effects of
IL-6 and its soluble receptor on
proteoglycan synthesis and NO release by human articular chondrocytes : comparison with IL-1 ... Contradictory results have been reported on the
effects and role of
IL-6 on
proteoglycan ( PG ) synthesis
Lubberts et al., Arthritis Rheum 2000
:
Reduction of
interleukin-17 induced inhibition of chondrocyte
proteoglycan synthesis in intact murine articular cartilage by interleukin-4
Dudler et al., Ann Rheum Dis 2000
(Arthritis) :
Effect of
interleukin 17 on
proteoglycan degradation in murine knee joints
Rickard et al., J Cell Biochem 2003
:
In hFOB/ERalpha9 cells, both genistein and E ( 2 ) increased the endogenous gene expression of the progesterone receptor (PR), the
proteoglycan versican, and alkaline phosphatase ( AP ), but
inhibited osteopontin (OP) gene expression and
interleukin-6 (IL-6) protein levels
Henderson et al., Cytokine 1991
(Synovitis) :
Inhibition of
interleukin-1 induced synovitis and articular cartilage
proteoglycan loss in the rabbit knee by recombinant human interleukin-1 receptor antagonist
Kandel et al., J Rheumatol 1990
:
Comparison of the
effect of interleukin 6 and
interleukin 1 on collagenase and
proteoglycan production by chondrocytes ... In order to determine whether interleukin 6 (IL-6) is involved in the pathogenesis of the cartilage destruction observed in arthritis, the
effect of human recombinant
IL-6 on collagenase production and
proteoglycan synthesis by bovine articular chondrocytes was examined
Nietfeld et al., Arthritis Rheum 1990
(Arthritis, Rheumatoid...) :
Interleukin-1 induced
interleukin-6 is
required for the inhibition of
proteoglycan synthesis by interleukin-1 in human articular cartilage
Heino et al., Biochem J 1988
:
Human recombinant
interleukin-1 regulates cellular mRNA levels of dermatan sulphate
proteoglycan core protein
Bocquet et al., Biochem Biophys Res Commun 1986
:
Effect of a
interleukin-1 like factor ( mononuclear cell factor ) on
proteoglycan synthesis in cultured human articular chondrocytes
Ratcliffe et al., Biochem J 1986
:
Characterization of the proteoglycans in the media after 1.5 days and 3 days of culture showed that
interleukin 1
promoted the release of
proteoglycan of large average size and also the release of link protein and of low-Mr binding region which was unattached to proteoglycan
Kato et al., J Biochem 1981
:
These findings suggest that the
stimulation of
proteoglycan synthesis by
CDF and MSA is not directly linked to the peptide induced stimulation of cell proliferation
Panthou et al., Biochem Mol Biol Int 1994
:
Effects of transforming growth factor-beta 1,
interleukin-1 alpha and interleukin-6 on rat Sertoli cell
proteoglycan synthesis
Sneed et al., Cell Immunol 1994
:
Interleukin-6 regulates expression of the syndecan-1
proteoglycan on B lymphoid cells ... We conclude that IL-6 participates in the regulation of syndecan-1 expression on B lymphoid cells and, given its broad distribution,
IL-6 may
regulate proteoglycan expression on other cell types as well
Platt et al., Equine Vet J 1994
:
An investigation of the
proteoglycan metabolism of mature equine articular cartilage and its
regulation by
interleukin-1
Van de Loo et al., Cytokine 1997
:
Effect of interleukin 1 and leukaemia inhibitory factor on chondrocyte metabolism in articular cartilage from normal and interleukin-6-deficient mice :
role of nitric oxide and
IL-6 in the suppression of
proteoglycan synthesis ... IL-1 dose dependently induced IL-6 synthesis and neutralizing
IL-6 with antibodies did not
reduce proteoglycan synthesis suppression, neither in explants nor in isolated chondrocytes