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INSIG1 — SREBF1

Pathways - manually collected, often from reviews:

• Reactome Reaction: INSIG1 → SREBF1 (direct_complex) Yang et al., Cell 2002*, Dobrosotskaya et al., J Biol Chem 2003*, Adams et al., Proc Natl Acad Sci U S A 2003*, Adams et al., J Biol Chem 2004*, Feramisco et al., Proc Natl Acad Sci U S A 2005*, Sun et al., J Biol Chem 2005*, Sakai et al., J Biol Chem 1997*
• Reactome Reaction: INSIG1 → SREBF1 (indirect_complex)
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: INSIG1/INSIG2 → Complex of INSIG1-SCAP-INSIG2-SREBF2-SREBF1 (mim-binding)
  
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: Complex of SCAP-SREBF2-SREBF1 → Complex of INSIG1-SCAP-INSIG2-SREBF2-SREBF1 (mim-binding)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: INSIG1 — SREBF1 (physical association, affinity chromatography technology) Yabe et al., Proc Natl Acad Sci U S A 2002*

Text-mined interactions from Literome

Lee et al., J Biol Chem 2008 : Unsaturated fatty acid mediated stabilization of Insig-1 enhances the ability of sterols to inhibit proteolytic activation of SREBP-1 , which activates transcription of genes involved in fatty acid synthesis
Chen et al., J Biomed Sci 2011 : Insig-1 effectively blocks the transcription of SREBP-1c , preventing the activation of the genes for lipid biosynthesis
Boden et al., Obesity (Silver Spring) 2013 : We conclude that these findings support the hypothesis that insulin stimulated activation of SREBP-1c in the liver, at least in part, by suppressing INSIG-1 and -2, whereas in adipose tissue, an increase in INSIG-1 and -2 prevented SREBP-1c activation
Kotzka et al., Biochem Biophys Res Commun 1998 : ADD1/SREBP-1c mediates insulin induced gene expression linked to the MAP kinase pathway