◀ Back to IL2
IL2 — JAK1
Pathways - manually collected, often from reviews:
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SOCS3
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SOCS1
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
IRS-1 (IRS1)
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SHP-1 (PTPN6)
(modification, activates)
-
BioCarta il 2 signaling pathway:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
SOCS3
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
(modification, inhibits)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
CBL
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SHP-1 (PTPN6)
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SOCS1
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2 (IL2)
→
IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-IL2RA-IL2RG-JAK1-JAK3)
(modification, collaborate)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2 (IL2)
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
(modification, collaborate)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-IL2RA-IL2RG-JAK1-JAK3)
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
(modification, collaborate)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SOCS3
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SOCS1
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
Nmi/STAT5 complex (NMI-STAT5A_STAT5B)
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SHP-1 (PTPN6)
(modification, activates)
-
BioCarta il 2 signaling pathway:
SYK
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
SYK
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
LCK
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
LCK
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
(modification, collaborate)
-
BioCarta il-2 receptor beta chain in t cell activation:
SOCS3
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
(modification, inhibits)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
CRKL
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SHP-1 (PTPN6)
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SOCS1
(modification, activates)
-
NCI Pathway Database IL2-mediated signaling events:
IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2R alpha (IL2RA)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2 (IL2)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2R gamma/JAK3 complex (IL2RG-JAK3)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3)
→
IL2 (IL2)
(modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1)
→
IL2 (IL2)
(modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK)
→
IL2 (IL2)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2 (IL2)
→
IL2R beta/JAK1/LCK/CISH complex (IL2RB-JAK1-LCK-CISH)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
Aiolos (IKZF3)
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
RasGAP/Dok-R complex (RASA1-DOK2)
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
SOCS3/RasGAP complex (SOCS3-RASA1)
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
None
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3)
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
None
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/PYK2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-PTK2B)
(modification, collaborate)
Miyazaki et al., Genes Dev 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
PYK2 (PTK2B)
(modification, collaborate)
Miyazaki et al., Genes Dev 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/PYK2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-PTK2B)
→
PYK2 (PTK2B)
(modification, collaborate)
Miyazaki et al., Genes Dev 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL2 signaling events mediated by PI3K:
None
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, collaborate)
Augustine et al., Mol Cell Biol 1991, Gómez et al., J Immunol 1997
Evidence: assay, other species
-
NCI Pathway Database IL2 signaling events mediated by PI3K:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
PKC zeta (PRKCZ)
(modification, activates)
Gómez et al., Exp Cell Res 1995, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK)
→
IL2 (IL2)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Burns et al., J Biol Chem 1993, Ravichandran et al., J Biol Chem 1994, Ravichandran et al., Proc Natl Acad Sci U S A 1996, Friedmann et al., Proc Natl Acad Sci U S A 1996, Lord et al., J Immunol 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
SHC (SHC1)
(modification, collaborate)
Burns et al., J Biol Chem 1993, Ravichandran et al., J Biol Chem 1994, Ravichandran et al., Proc Natl Acad Sci U S A 1996, Friedmann et al., Proc Natl Acad Sci U S A 1996, Lord et al., J Immunol 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
SHC (SHC1)
(modification, collaborate)
Burns et al., J Biol Chem 1993, Ravichandran et al., J Biol Chem 1994, Ravichandran et al., Proc Natl Acad Sci U S A 1996, Friedmann et al., Proc Natl Acad Sci U S A 1996, Lord et al., J Immunol 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK)
→
IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2 (IL2)
→
IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2R gamma/JAK3 complex (IL2RG-JAK3)
→
IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3)
(modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3)
→
PKC beta (PRKCB)
(modification, activates)
Gómez et al., Exp Cell Res 1995
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
Dok-R (DOK2)
(modification, activates)
Nelms et al., Immunity 1998
-
NCI Pathway Database SHP2 signaling:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database SHP2 signaling:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database SHP2 signaling:
PI3K complex (PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database SHP2 signaling:
RHOA/GTP complex (RHOA)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, activates)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
STAT1 (STAT1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Delespine-Carmagnat et al., Eur J Immunol 2000, Frank et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995
Evidence: assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
STAT1 (dimer) complex (STAT1)
(modification, activates)
Delespine-Carmagnat et al., Eur J Immunol 2000, Frank et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995
Evidence: assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Zhu et al., J Biol Chem 1994, Ravichandran et al., J Biol Chem 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
GAB2/GRB2/SOS1 complex (GRB2-SOS1-GAB2)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Zhu et al., J Biol Chem 1994, Ravichandran et al., J Biol Chem 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
GAB2/GRB2/SOS1 complex (GRB2-SOS1-GAB2)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Zhu et al., J Biol Chem 1994, Ravichandran et al., J Biol Chem 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
Erk1-2-active (MAPK3/MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
SHP2 (PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
SHP2 (PTPN11)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
SHP2 (PTPN11)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, inhibits)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, inhibits)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
STAT5 (STAT5A/STAT5B)
(modification, activates)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
STAT5 (dimer)-active (STAT5B/STAT5A)
(modification, activates)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1)
(modification, collaborate)
Augustine et al., Mol Cell Biol 1991
Evidence: assay, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Augustine et al., Mol Cell Biol 1991
Evidence: assay, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Augustine et al., Mol Cell Biol 1991
Evidence: assay, other species
-
NCI Pathway Database IL2 signaling events mediated by PI3K:
None
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Gu et al., Mol Cell Biol 2000, Lindemann et al., J Biol Chem 2003, Akbar et al., Eur J Immunol 1996, Ahmed et al., Proc Natl Acad Sci U S A 1997, Reif et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Tsujino et al., Genes Cells 1999, Merida et al., J Immunol 1991, Taichman et al., J Biol Chem 1993, González-García et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3-PIK3CA-PIK3R1)
→
IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3)
(modification, collaborate)
Tsujino et al., Genes Cells 1999, Merida et al., J Immunol 1991, Taichman et al., J Biol Chem 1993, González-García et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3)
(modification, collaborate)
Tsujino et al., Genes Cells 1999, Merida et al., J Immunol 1991, Taichman et al., J Biol Chem 1993, González-García et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database SHP2 signaling:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
SHP2 (PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database SHP2 signaling:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
RHOA/GTP complex (RHOA)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, activates)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database SHP2 signaling:
SHP2 (PTPN11)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2 signaling events mediated by STAT5:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
→
STAT5 (dimer)-active (STAT5B/STAT5A)
(transcription, activates)
Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
IL2 (IL2)
(modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
IL2R gamma/JAK3 complex (IL2RG-JAK3)
(modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3)
→
IL2R beta/JAK1/Fyn complex (IL2RB-JAK1-FYN)
(modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2 (IL2)
→
IL2R beta/JAK1/Fyn complex (IL2RB-JAK1-FYN)
(modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IRS1-2 (IRS2/IRS1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IRS1-2 (IRS2/IRS1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
RAF1 (RAF1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
SYK (SYK)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
SYK (SYK)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
(modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
(modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
p38alpha-beta-active (MAPK14/MAPK11)
(modification, activates)
Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1)
→
p38alpha-beta (MAPK14/MAPK11)
(modification, activates)
Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Jiang et al., Blood 2003
Evidence: mutant phenotype
-
NCI Pathway Database IL2-mediated signaling events:
None
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
RHOA/GTP complex (RHOA)
(modification, activates)
Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
None
(modification, activates)
Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
PP2A (PPP2R5D)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(positive regulation of cell-cell adhesion, collaborate)
Brockdorff et al., Cytokine 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database SHP2 signaling:
RAF1 (RAF1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1)
(modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/STAM1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-STAM2_STAM)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Endo et al., FEBS Lett 2000, Takeshita et al., Immunity 1997
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/STAM1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-STAM2_STAM)
→
STAM1-2 (STAM2/STAM)
(modification, collaborate)
Endo et al., FEBS Lett 2000, Takeshita et al., Immunity 1997
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
STAM1-2 (STAM2/STAM)
(modification, collaborate)
Endo et al., FEBS Lett 2000, Takeshita et al., Immunity 1997
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL2 signaling events mediated by PI3K:
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3-PIK3CA-PIK3R1)
→
BCL-X (BCL2L1)
(transcription, activates)
González-García et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
STAT3 (STAT3)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Delespine-Carmagnat et al., Eur J Immunol 2000, Fung et al., Cell Signal 2003, Nielsen et al., Eur J Immunol 1994, Frank et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Ng et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
MEK1-2 (MAP2K1/MAP2K2)
(modification, activates)
Delespine-Carmagnat et al., Eur J Immunol 2000, Fung et al., Cell Signal 2003, Nielsen et al., Eur J Immunol 1994, Frank et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Ng et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
IL2
→
JAK1
(indirect_complex)
Rickert et al., J Mol Biol 2004, Stauber et al., Proc Natl Acad Sci U S A 2006
-
Reactome Reaction:
IL2
→
JAK1
(reaction)
Zhou et al., Mol Cell Biol 2000, Rickert et al., J Mol Biol 2004, Stauber et al., Proc Natl Acad Sci U S A 2006, Johnston et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Nature 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996
-
Reactome Reaction:
IL2
→
JAK1
(direct_complex)
Friedmann et al., Proc Natl Acad Sci U S A 1996
Text-mined interactions from Literome
Sudarshan et al., J Immunol 1999
:
Similarly, but in contrast to previous reports, we found that TGF-beta1 did not inhibit
IL-2 induced phosphorylation of
JAK1 , JAK3, and STAT5A ... Similarly, but in contrast to previous reports, we found that TGF-beta1 did not inhibit
IL-2 induced phosphorylation of JAK1,
JAK3 , and STAT5A
Cohney et al., Mol Cell Biol 1999
:
In these experiments, SOCS-3 associated with Jak1 and
inhibited Jak1 phosphorylation, and this inhibition was markedly enhanced by the presence of
IL-2 receptor beta chain (IL-2Rbeta)
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of
JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Yu et al., J Immunol 2000
:
However, one T cell line bearing a mutant gammac exhibited impaired endocytosis of IL-2, despite normal
IL-2 induced
Jak/STAT activation
Kulms et al., J Biol Chem 2001
:
In contrast,
IL-2 induced tyrosine phosphorylation of the kinases
Jak1 and Jak3 located upstream of STAT5 was not affected by UV
Bovolenta et al., Clin Immunol 2001
(HIV Infections) :
In particular,
IL-2 activates the tyrosine kinases
JAK1 and JAK3 and the transcription factors STAT3 and STAT5
Tkaczuk et al., Am J Transplant 2002
(MAP Kinase Signaling System) :
Effect of anti-IL-2Ralpha antibody on
IL-2 induced
Jak/STAT signaling ... Under these circumstances,
IL-2 mediated
Jak/STAT pathway
activation might be generated through residual intermediate affinity IL-2Rbetagamma receptors, and this was demonstrated by complete blockade of signaling when anti-IL-2Rbeta monoclonal antibody was added
Kryworuchko et al., Clin Exp Immunol 2003
:
Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit
interleukin-2 induced
Jak/STAT signalling in human CD4 T lymphocytes ... The treatment of CD4 T cells with HIV env or surface ligation of CD4 with anti-CD4 monoclonal antibodies inhibited the
IL-2 induced activation of
Jak-1 and Jak-3, as well as their targets, STAT5a and STAT5b
Zhang et al., J Immunol 2004
:
In this study, we show that adenosine suppressed IL-2 dependent proliferation of CTLL-2 T cells by inhibiting STAT5a/b tyrosine phosphorylation that is associated with IL-2R signaling without affecting
IL-2 induced phosphorylation of
Jak1 or Jak3
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Ozawa et al., J Immunol 2004
(Periodontitis) :
Pretreatment with anti-IL-15 neutralizing mAb for 24 h completely inhibited the production of MCP-1 induced by IL-2 and IL-15 and
IL-2 induced phosphorylation of
Jak 1 and 3 in HGF
Anderson et al., J Immunol 2005
:
Although IL-2 expression was deficient, stimulation with
IL-2 in vitro
induced Jak1 and STAT5 activation in PI-T ( Reg ) cells, restored their proliferative response to antigenic stimulation, and abrogated PI-T ( Reg ) -mediated suppression in vitro
Fujii et al., Biochem Biophys Res Commun 2007
:
Here, I showed that Jak3 expression is dispensable for
IL-2 induced
activation of
Jak1 and Stat proteins and expression of nuclear proto-oncogenes in the IL-2R reconstituted fibroblast cell line
Gorjão et al., J Lipid Res 2007
:
PA, SA, DHA, and EPA decreased
JAK1 , JAK3, STAT5, and Akt phosphorylation
induced by
IL-2 , but OA and LA did not cause any effect ... PA, SA, DHA, and EPA decreased JAK1,
JAK3 , STAT5, and Akt phosphorylation
induced by
IL-2 , but OA and LA did not cause any effect
Lindemann et al., J Biol Chem 2008
:
Cells expressing this mutant IL-2Rbeta chain fail to induce phosphorylation of PI3K-p85alpha/beta or activate Akt, but mediate normal
IL-2 dependent proliferation and activation of
JAK1 and STAT-5A/B. Microarray analyses revealed differential regulation of numerous genes compared with cells expressing a wild-type IL-2Rbeta, including up-regulation of the IL-17 receptor subunit IL-17RA
Ross et al., J Biol Chem 2010
:
Moreover, inhibition of PP2A, but not PP1, diminished
IL-2 induced tyrosine phosphorylation of IL-2Rbeta,
JAK3 , and STAT5, and abolished STAT5 DNA binding activity
Karitskaya et al., Pflugers Arch 2010
:
The pharmacological inhibition of
IL-2 induced MEK/ERK or
JAK/STAT cascades suppressed the IL-2 induced proliferation and reduced the functional and protein expressions of Na, K-ATPase
Sewgobind et al., Am J Transplant 2010
:
In this study, we examined the effect of CP-690,550 on
IL-2 mediated
Jak/STAT5 phosphorylation by CD4 ( + ) CD25 ( bright ) FoxP3 ( + ) CD127 ( -/low ) T cells ( Treg ) and CD4 ( + ) CD25 ( neg ) effector T cells ( Teff ) in kidney transplant ( KTx ) patients
Forward et al., Biochem Biophys Res Commun 2011
:
IL-2 induced phosphorylation of STAT5A and JAK3, but not
JAK1 , was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling
Soth et al., J Med Chem 2013
:
Evaluation of this analogue in cellular and in vivo models confirmed functional selectivity for modulation of a
JAK3/JAK1 dependent
IL-2 stimulated pathway over a JAK1/JAK2/Tyk2 dependent IL-6 stimulated pathway
Brunn et al., J Biol Chem 1995
:
Both
IL-2 and IL-4
stimulated the rapid activation of
JAK1 and JAK3, whereas JAK2 activity was unaffected by either cytokine
Wakao et al., EMBO J 1995
:
Analysis of two EPO receptor (EPOR) transfected CTLL-2 cell lines discloses that
IL-2 activates
JAK1 and JAK3 as well as STAT5, while EPO stimulates STAT5 and JAK2 in EPO-responsive CTLL-2 cells ( ERT/E2 )
Barber et al., Mol Cell Biol 1994
:
In contrast, stimulation with
IL-2 or the related cytokine IL-4
resulted in the rapid, dose dependent tyrosine phosphorylation of
JAK1 and an additional 116-kDa protein ... Immune complex kinase assays confirmed that
IL-2 and IL-4
activated JAK1 and EPO activated JAK2
Russell et al., Science 1994
(Severe Combined Immunodeficiency) :
IL-2 , IL-4, IL-7 ( whose receptors are known to contain gamma c ), and IL-9 ( whose receptor is shown here to contain gamma c )
induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases
Jak1 and Jak3
Miyazaki et al., Science 1994
:
Functional
activation of
Jak1 and Jak3 by selective association with
IL-2 receptor subunits ... Stimulation with
IL-2 induces the tyrosine phosphorylation and activation of the Janus kinases
Jak1 and Jak3
Beadling et al., EMBO J 1994
:
An
IL-2 induced increase in
JAK1 and JAK3, but not JAK2 or Tyk2, tyrosine phosphorylation was observed ... The observation that
IL-2 and IFN alpha
activate JAK1 to a comparable degree, but only IFN alpha activates STAT1, indicates that JAK1 activation is not the only determining factor for STAT1 activation
Johnston et al., Nature 1994
:
Phosphorylation and activation of the Jak-3
Janus kinase in
response to
interleukin-2
Taylor et al., Blood 1996
(Severe Combined Immunodeficiency) :
IL-2 stimulation of the transduced cell line
resulted in appropriate tyrosine phosphorylation of both
Jak1 and Jak3
Yu et al., J Immunol 1996
:
Finally,
IL-2 induced tyrosine phosphorylation of
JAK1 and JAK3, while IL-12 induced phosphorylation of JAK2 and TYK2 in both preactivated primary NK and NK3.3 cells
Ferrag et al., Mol Endocrinol 1996
:
Otherwise,
Jak1 and Jak3 are
involved in
IL-2 signaling through heterodimerization of the IL-2 receptor-beta (IL-2R beta) and gamma c-chains
Oakes et al., Immunity 1996
(Severe Combined Immunodeficiency) :
Although
IL-2 induced phosphorylation of IL-2R beta,
JAK1 , and STAT5 all required the presence of JAK3, IL-4 mediated phosphorylation of JAK1, STAT6, and insulin receptor substrates 1 and 2 did not ... Although
IL-2 induced phosphorylation of IL-2R beta,
JAK1 , and STAT5 all required the presence of JAK3, IL-4 mediated phosphorylation of JAK1, STAT6, and insulin receptor substrates 1 and 2 did not
Yu et al., J Biol Chem 1997
:
Activation of
Jak and STAT proteins by
IL-2 is transient and the mechanism for the subsequent down-regulation of their activity is largely unknown
Bright et al., J Immunol 1997
:
TGF-beta inhibits
IL-2 induced tyrosine phosphorylation and
activation of
Jak-1 and Stat 5 in T lymphocytes ... We show here that treatment of activated T cells with TGF-beta inhibited
IL-2 induced tyrosine phosphorylation and
activation of
Jak-1 and Stat 5 but not Jak-3 and Stat 3
Liu et al., Curr Biol 1997
(Fibrosarcoma) :
Furthermore, the relative
roles of
JAK1 and JAK3 in the activation of STAT5 by
interleukin-2 (IL-2) remain poorly understood
Ferrag et al., FEBS Lett 1998
:
Heterotrimeric
IL-2R ( alpha, beta, gamma[c ] chains )
activates Jak1 and Jak3, whereas homodimeric PRLR activates Jak2
Zhu et al., J Biol Chem 1998
:
Moreover,
Jak1 and Jak3 could associate only in the
presence of
IL-2Rbeta , suggesting that these kinases can simultaneously bind to IL-2Rbeta
Migone et al., Mol Cell Biol 1998
:
Instead, we find that
Jak1 , which associates with membrane-proximal regions of the IL-2Rbeta cytoplasmic domain, is
essential for efficient
IL-2Rbeta-p85 interaction, although some IL-2Rbeta-p85 association can be seen in the absence of Jak1