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MAPK1 — MUC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK1 → MUC1 (increases, MUC1 Activity)
  Evidence: Indeed, mucin1 is also overexpressed in breast cancers and tyrosine phosphorylation of the CT domain of MUC1 mucin leads to activation of amitogen-activated protein kinase pathway through the Ras-MEK-ERK2 pathway (38, 39).

Text-mined interactions from Literome

McNamara et al., Am J Respir Cell Mol Biol 2006 : The induction of mucin by flagellin in human lung epithelial cells ( NCIH292 ) is dependent on asialoGM1 ligation, ATP receptor signaling, Ca2+ mobilization, and Erk1/2 activation
Ríos et al., Exp Eye Res 2008 (MAP Kinase Signaling System) : The purpose of the study was to determine if OPC-12759 stimulates secretion from conjunctival goblet cells in culture and if it activates the EGF receptor (EGFR) and p44/p42 mitogen activated protein kinase ( MAPK ) to cause mucin secretion
Román et al., Eukaryotic cell 2009 (Candidiasis) : Msb2 signaling mucin controls activation of Cek1 mitogen activated protein kinase in Candida albicans
Besmer et al., Cancer Res 2011 (Carcinoma, Pancreatic Ductal...) : Treatment with a MEK1/2 inhibitor, U0126, abrogated the enhanced proliferation of the KCM cells but had minimal effect on KCKO cells, suggesting that MUC1 is necessary for MAPK activity and oncogenic signaling
Kato et al., J Immunol 2012 (Lung Diseases...) : However, overexpression of MUC1 in HEK293 cells did not affect NF-?B or MAPK activation in response to TNF-a
Hodges et al., Exp Eye Res 2012 : Inhibitors against the EGF receptor and ERK 1/2 also blocked Cch stimulated mucin secretion