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DHCR24 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: TP53 — DHCR24 Wu et al., Nature 2004*
• IRef Bind_translation Interaction: TP53 — DHCR24 (coimmunoprecipitation) Wu et al., Nature 2004*
• IRef Biogrid Interaction: DHCR24 — TP53 (physical association, affinity chromatography technology) Wu et al., Nature 2004*
• IRef Hprd Interaction: TP53 — DHCR24 (in vivo) Wu et al., Nature 2004*

Text-mined interactions from Literome

Wu et al., Nature 2004 (Cell Transformation, Neoplastic) : Following oncogenic and oxidative stress, Seladin-1 binds p53 amino terminus and displaces E3 ubiquitin ligase Mdm2 from p53, thus resulting in p53 accumulation
Nishimura et al., J Biol Chem 2009 (Cell Transformation, Viral...) : Ectopic or HCV induced DHCR24 overexpression resulted in resistance to oxidative stress induced apoptosis and suppressed p53 activity ... Taken together, these results suggest that DHCR24 is elevated in response to HCV infection and inhibits the p53 stress response by stimulating the accumulation of the MDM2-p53 complex in the cytoplasm and by inhibiting the acetylation of p53 in the nucleus