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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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DIO1 — LEP

Text-mined interactions from Literome

Wilsey et al., J Endocrinol 2004 : Leptin induced a > 6-fold increase in STAT3 phosphorylation in CHOW rats, but less than 2-fold increase in DIO ... CR resulted in a 45 and 85 % increase respectively in leptin stimulated STAT3 phosphorylation in CHOW and DIO animals
Brabant et al., FASEB J 2005 (Insulin Resistance...) : The aim of the present study was to evaluate the effects of DIO on leptin and insulin cross signaling in the liver
Levin et al., Int J Obes Relat Metab Disord 2006 (Obesity...) : DIO and DR rats ran comparable amounts but only the DIO rats reduced their body weight gain, fat pad relative to body weights and plasma leptin levels significantly, compared to their sedentary controls
Kim et al., J Nutr Biochem 2012 (Inflammation...) : This study investigates the role of the visceral as well as subcutaneous adipose tissues in the development of metaflammation by characterizing the tissue-specific expression profiles of TLRs and downstream signaling molecules and explores the differential responsiveness of TLR mediated proinflammatory signaling cascades to diet induced obesity ( DIO ) and obesity induced by a leptin gene deficiency