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IL18R1 — RELA

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: IL18/IL18R complex (IL18-IL18R1-IL18RAP) → NF kappa B1 p50/RelA complex (NFKB1-RELA) (translocation, activates)
  Lawless et al., J Immunol 2000, Grohmann et al., Immunity 1998
  Evidence: mutant phenotype, assay, other species

Text-mined interactions from Literome

Towne et al., J Biol Chem 2004 (MAP Kinase Signaling System) : In this study, we demonstrate that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2 dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines
Born et al., J Biol Chem 1998 : We found that both IL-1R-rp1 and AcPL expression were required for induction of NFkappaB activity and for activation of c-Jun N-terminal kinase in response to IL-18