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NFKB1 — SFN

Text-mined interactions from Literome

Heiss et al., J Biol Chem 2001 : SFN selectively reduced DNA binding of NF-kappa B without interfering with LPS induced degradation of the inhibitor of NF-kappa B nor with nuclear translocation of NF-kappa B
Choi et al., Carcinogenesis 2007 (Prostatic Neoplasms) : The effect of SFN on levels of IAP family proteins as well as transcriptional activity of NFkappaB was biphasic in LNCaP cells
Moon et al., Cancer Lett 2009 (Neoplasms) : We also report that SFN non-specifically inhibited TNF-alpha induced NF-kappaB activation through the inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, and p65 nuclear translocation ... These effects suggest that SFN inhibits TNF-alpha induced NF-kappaB activation through the suppression of IkappaBalpha degradation, leading to reduced expression of NF-kappaB regulated gene products ... In conclusion, the results of the present study indicate that SFN suppresses TNF-alpha induced NF-kappaB activity and induces apoptosis through activation of ROS dependent caspase-3
Youn et al., J Immunol 2010 : SFN formed adducts with cysteine residues in the extracellular domain of TLR4 as confirmed by liquid chromatography-tandem mass spectrometry analysis and the inhibitory effects of SFN on oligomerization and NF-kappaB activation were reversed by thiol donors ( DTT and N-acetyl-L-cysteine )