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CD44 — EGFR

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: CD44 — EGFR (coimmunoprecipitation) Tsatas et al., J Clin Neurosci 2002*
• IRef Biogrid Interaction: EGFR — CD44 (physical association, affinity chromatography technology) Tsatas et al., J Clin Neurosci 2002*
• IRef Hprd Interaction: CD44 — EGFR (in vivo) Tsatas et al., J Clin Neurosci 2002*
• IRef Ophid Interaction: CD44 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ghatak et al., J Biol Chem 2005 (Breast Neoplasms...) : In this study we show that constitutively high levels of active, i.e. autophosphorylated, ErbB2 in HCT116 colon carcinoma cells and TA3/St mammary carcinoma cells are dependent on endogenous hyaluronan-CD44 interaction
Hatano et al., Lab Invest 2011 (Fibroma, Ossifying) : The results raise the novel idea that the EGFR may activate Raf-MEK-ERK signaling in response to the binding of HA to CD44
Yu et al., Mol Cell Biochem 2011 : The aim of our study was to examine the role of HA and CD44 in ROS induced EGFR activation and MUC5AC expression
Kim et al., Anticancer Res 2011 (Breast Neoplasms) : In contrast, EGFR ligand induced CD44 expression was reduced by EGFR inhibitors, AG1478 and lapatinib, respectively
Abhold et al., PloS one 2012 (Carcinoma, Squamous Cell...) : Activation of EGFR by the addition of EGF ligand or ectopic expression of EGFR in two established HNSCC cell lines ( UMSCC-22B and HN-1 ) resulted in the induction of CD44 , BMI-1, Oct-4, NANOG, CXCR4, and SDF-1
Perez et al., Oral Oncol 2013 (Carcinoma, Squamous Cell...) : Downregulation of CD44 in CAL27 cells inhibited constitutive EGFR phosphorylation and significantly reduced tumor growth in nude mice