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EIF2AK2 — IFNG

Text-mined interactions from Literome

Taga et al., Mol Cell Endocrinol 1999 : To clarify the biological significance of double stranded RNA dependent protein kinase ( PKR ), an interferon (INF)-inducible substance, we investigated ( 1 ) PKR gene expression and the ( 2 ) effect of IFN-gamma on PKR gene expression in human endometrium
Tanaka et al., Gene 2000 : Northern blot analysis showed efficient IFN-alpha induced accumulation of 2.4kb, 4.5kb and approx. 6kb Pkr transcripts, but neither IFN-gamma nor IL-6 induced detectable Pkr mRNA accumulation in L cells
Deb et al., J Immunol 2001 : RNA dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1 independent pathway ... There was no activation of NF-kappaB by IFN in PKR-null cells, indicating that PKR is required for IFN-gamma signaling to NF-kappaB
Maggi et al., J Biol Chem 2002 : PKR does not participate in iPLA ( 2 ) activation or iNOS expression, because dsRNA stimulates iPLA ( 2 ) activity and dsRNA + IFN-gamma induces iNOS expression and nitric oxide production to similar levels by macrophages isolated from PKR ( +/+ ) and PKR ( -/- ) mice
Chesler et al., Viral Immunol 2003 : PKR is not required for interferon-gamma inhibition of VSV replication in neurons ... These data indicate that endogenously expressed PKR is not required for the IFN-gamma mediated inhibition of VSV replication in NB41A3 neuroblastoma cells
Austin et al., J Interferon Cytokine Res 2006 : Involvement of OAS and PKR in IFN-gamma induced anti-herpes simplex virus-1 ( HSV-1 ) pathways has not been reported previously, but IFN-gamma induces OAS and PKR when other viruses invade the nervous system ... The aim of the current study was to determine if the absence of intact OAS and PKR antiviral pathways affects the antiviral activity of IFN-gamma during acute HSV-1 infection within the trigeminal ganglia ( TG )
Bennett et al., Blood 2006 (Inflammation...) : Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Kang et al., J Clin Invest 2008 (Virus Diseases) : The effects of a combination of CS and poly ( I:C ) were associated with early induction of type I IFN and IL-18, later induction of IL-12/IL-23 p40 and IFN-gamma , and the activation of double stranded RNA dependent protein kinase ( PKR ) and eukaryotic initiation factor-2alpha ( eIF2alpha )
Kadereit et al., J Interferon Res 1994 : For example, in HeLa cells, IFN-alpha or IFN-beta induced similarly both PKR and p48 whereas IFN-gamma induced mainly p48