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CSF2 — RAF1
Text-mined interactions from Literome
Kawaguchi et al., J Allergy Clin Immunol 2004
:
Selective MEK inhibitors, PD98059 and U0126, and
Raf1 kinase inhibitor I significantly
inhibited ML-1 induced
GM-CSF production ... Furthermore, overexpression of
Raf1 dominant negative mutants
inhibited IL-17F induced
GMCSF expression
Carroll et al., J Biol Chem 1990
:
Interleukin-3 and granulocyte-macrophage
colony stimulating factor mediate rapid phosphorylation and activation of cytosolic
c-raf ... Interleukin-3 (IL-3) and granulocyte-macrophage
colony stimulating factor induce the rapid phosphorylation of the
c-raf protein in the growth factor dependent FDC-P1 and DA-3 murine myeloid cell lines ... IL-3 and granulocyte-macrophage
colony stimulating factor induce phosphorylation of
c-raf at both serine and tyrosine residues
Miyazawa et al., Exp Hematol 1991
:
Both MGF and
GM-CSF enhanced Raf-1 phosphorylation and
increased Raf-1 associated kinase activity in vitro
Kanakura et al., Blood 1991
:
Granulocyte-macrophage
colony stimulating factor and interleukin-3
induce rapid phosphorylation and activation of the proto-oncogene
Raf-1 in a human factor dependent myeloid cell line ...
GM-CSF and IL-3 rapidly and transiently
increased Raf-1 kinase activity using Histone H1 as a substrate in an immune complex kinase assay in vitro
Büscher et al., Mol Cell Biol 1995
:
Therefore,
CSF-1 and LPS target the MAPK network by two alternative pathways, both of which
induce Raf-1 activation
Csar et al., Biochem J 1997
(Leukemia, Myeloid) :
cAMP suppresses p21ras and
Raf-1 responses but not the Erk-1
response to
granulocyte-colony stimulating factor : possible Raf-1 independent activation of Erk-1
Aronica et al., Blood 1997
(Leukemia, Megakaryoblastic, Acute) :
Granulocyte-macrophage
colony stimulating factor ( GM-CSF ) and Steel factor ( SLF ) synergistically
stimulate Raf-1 kinase activity, protein synthesis, and proliferation in hematopoietic MO7e cells ; synergistic action of these factors is blocked by the suppressive chemokines macrophage inflammatory protein-1alpha ( MIP-1alpha ) and interferon-inducible protein 10 ( IP-10 ; Aronica et al, J Biol Chem 270 : 21998, 1995 )
McLeish et al., J Leukoc Biol 1998
:
GM-CSF , but not TNF-alpha,
stimulated wortmannin-sensitive activation of
Raf-1