Gene interactions and pathways from curated databases and text-mining

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CSF2 — RAF1

Text-mined interactions from Literome

Kawaguchi et al., J Allergy Clin Immunol 2004 : Selective MEK inhibitors, PD98059 and U0126, and Raf1 kinase inhibitor I significantly inhibited ML-1 induced GM-CSF production ... Furthermore, overexpression of Raf1 dominant negative mutants inhibited IL-17F induced GMCSF expression
Carroll et al., J Biol Chem 1990 : Interleukin-3 and granulocyte-macrophage colony stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf ... Interleukin-3 (IL-3) and granulocyte-macrophage colony stimulating factor induce the rapid phosphorylation of the c-raf protein in the growth factor dependent FDC-P1 and DA-3 murine myeloid cell lines ... IL-3 and granulocyte-macrophage colony stimulating factor induce phosphorylation of c-raf at both serine and tyrosine residues
Miyazawa et al., Exp Hematol 1991 : Both MGF and GM-CSF enhanced Raf-1 phosphorylation and increased Raf-1 associated kinase activity in vitro
Kanakura et al., Blood 1991 : Granulocyte-macrophage colony stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor dependent myeloid cell line ... GM-CSF and IL-3 rapidly and transiently increased Raf-1 kinase activity using Histone H1 as a substrate in an immune complex kinase assay in vitro
Büscher et al., Mol Cell Biol 1995 : Therefore, CSF-1 and LPS target the MAPK network by two alternative pathways, both of which induce Raf-1 activation
Csar et al., Biochem J 1997 (Leukemia, Myeloid) : cAMP suppresses p21ras and Raf-1 responses but not the Erk-1 response to granulocyte-colony stimulating factor : possible Raf-1 independent activation of Erk-1
Aronica et al., Blood 1997 (Leukemia, Megakaryoblastic, Acute) : Granulocyte-macrophage colony stimulating factor ( GM-CSF ) and Steel factor ( SLF ) synergistically stimulate Raf-1 kinase activity, protein synthesis, and proliferation in hematopoietic MO7e cells ; synergistic action of these factors is blocked by the suppressive chemokines macrophage inflammatory protein-1alpha ( MIP-1alpha ) and interferon-inducible protein 10 ( IP-10 ; Aronica et al, J Biol Chem 270 : 21998, 1995 )
McLeish et al., J Leukoc Biol 1998 : GM-CSF , but not TNF-alpha, stimulated wortmannin-sensitive activation of Raf-1