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CDK4 — MAPK8
Text-mined interactions from Literome
Liu et al., Di Yi Jun Yi Da Xue Xue Bao 2002
(Cardiomyopathy, Hypertrophic...) :
[
Regulation of
cyclin dependent kinase inhibitors by
mitogen activated protein kinase in angiotensin II-stimulated vascular smooth muscle cell hypertrophy ] ... To investigate the
role of mitogen activated protein kinase (
MAPK ) in the regulation of
cyclin dependent kinase inhibitors ( CDKI ) in the process of vascular smooth muscle cell ( VSMC ) hypertrophy induced by angiotensin II stimulation
Lee et al., J Cell Biochem 2006
:
In addition, PD 98059 ( a MEK inhibitor ), SB 203580 ( a p38
MAPK inhibitor ), and SP 600125 ( a JNK inhibitor )
blocked the EGF induced stimulation of [ 3H ] -thymidine incorporation and
CDK-2/4 expression
Benson et al., Blood 2009
(MAP Kinase Signaling System) :
The effect results at least in part via enhanced
MAPK mediated modulation of p27 and
CDK4
Brennan et al., J Med Food 2012
(Adrenocortical Carcinoma) :
BME treatment enhanced cellular tumor antigen p53,
cyclin dependent kinase inhibitor 1A ( also called p21 ), and cyclic AMP dependent transcription factor-3 levels and
inhibited G1/S-specific cyclin D1, D2, and D3, and
mitogen activated protein kinase 8 ( also called Janus kinase ) expression, suggesting an additional mechanism involving cell cycle regulation and cell survival