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ADAM10 — ADAM21
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Peng et al., Neuroscience 2007
(Alzheimer Disease...) :
Hup A enhanced the level of
ADAM10 , and the inhibitor of tumor necrosis factor-alpha converting enzyme ( TACE )
/ADAM17 inhibited the Hup A-induced rise in alphaAPPs levels, further suggesting Hup A directed APP metabolism toward the non-amyloidogenic alpha-secretase pathway
Linford et al., Dev Cell 2012
:
In FAM116A- and Rab14 depleted cells,
ADAM10 accumulates in a transferrin positive endocytic compartment, and the cell-surface level of
ADAM10 is correspondingly
reduced