Gene interactions and pathways from curated databases and text-mining

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CDKN1A — HDAC10

Text-mined interactions from Literome

Xiao et al., J Cell Biochem 1999 : Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells
Sowa et al., Cancer Res 1999 : Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor
Xiao et al., J Biol Chem 2000 : p300 collaborates with Sp1 and Sp3 in p21 ( waf1/cip1 ) promoter activation induced by histone deacetylase inhibitor
Shin et al., Cancer Res 2000 (Stomach Neoplasms) : The p21 gene was activated only by histone deacetylase inhibitor
Claassen et al., Proc Natl Acad Sci U S A 2000 : Repression of p21 ( CIP1 ) transcription by c-Myc occurred at the promoter level in a region near the start site of transcriptional initiation and was independent of histone deacetylase activity
Huang et al., Oncogene 2000 (Breast Neoplasms) : Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid ( SAHA ) through the Sp1 sites
Sowa et al., Biofactors 2000 (Colorectal Neoplasms...) : As a model of this, we found that histone deacetylase inhibitors such as butyrate or trichostatin A dramatically stimulate the p21/WAF1 gene promoter through the Spl sites, resulting in cell cycle arrest
Han et al., J Biol Chem 2001 : Activation of p21 ( WAF1/Cip1 ) transcription through Sp1 sites by histone deacetylase inhibitor apicidin : involvement of protein kinase C
Burgess et al., Mol Pharmacol 2001 : Up-regulation of p21 ( WAF1/CIP1 ) by histone deacetylase inhibitors reduces their cytotoxicity
Blagosklonny et al., Mol Cancer Ther 2002 : By preventing deacetylation of histones, histone deacetylase inhibitors ( HDIs ) transcriptionally induce p21
Sowa et al., Nihon Eiseigaku Zasshi 2003 (Neoplasms) : As a model of our hypothesis, we found that histone deacetylase inhibitors such as butyrate and trichostatin A dramatically stimulate the p21/WAF1 gene promoter through the Sp1 sites, resulting in cell cycle arrest
Piekarz et al., Blood 2004 (Lymphoma, T-Cell) : Treatment with depsipeptide, as well as other histone deacetylase inhibitors, caused induction of histone acetylation, induction of p21 expression, and substantial apoptosis without significant cell cycle arrest