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LEP — ROCK1

Text-mined interactions from Literome

Zeidan et al., J Pharmacol Exp Ther 2007 (Hypertrophy) : Our results indicate that the activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
Moey et al., J Pharmacol Exp Ther 2011 (Cardiomegaly) : The stimulation of RhoA/ROCK by leptin was associated with significantly increased p115RhoGEF gene and protein expression and exchange activity, all of which were completely prevented by ginseng ... The ability of ginseng to prevent leptin induced activation of RhoA/ROCK was further associated with diminished p38 MAPK activation and nuclear translocation
Huang et al., Nat Neurosci 2012 (Obesity) : Leptin promoted the physical interaction of JAK2 and ROCK1 , thereby increasing phosphorylation of JAK2 and downstream activation of Stat3 and FOXO1