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BCL2 — CYCS

Pathways - manually collected, often from reviews:

• BioCarta role of mitochondria in apoptotic signaling: BAX/BCL-2/BCL-XL complex (BAX-BCL2-BCL2L1) → cytochrome C (CYCS) (translocation, activates)
• BioCarta stress induction of hsp regulation: BCL-2 (BCL2) → cytochrome C (CYCS) (translocation, inhibits)
• BioCarta role of mitochondria in apoptotic signaling: BCL-XL/BCL-2/BAK complex (BCL2L1-BCL2-BAK1) → cytochrome C (CYCS) (translocation, activates)
• BioCarta apoptotic signaling in response to dna damage: BCL-2 (BCL2) → cytochrome C (CYCS) (translocation, inhibits)
• KEGG Amyotrophic lateral sclerosis (ALS): BCL2 → CYCS (protein-protein, missing interaction)
• KEGG Tuberculosis: BCL2 → Complex of APAF1-CASP9-CYCS (protein-protein, inhibition)
  
• KEGG Pathways in cancer: BCL2 → CYCS (protein-protein, inhibition)
• NCI Pathway Database Ceramide signaling pathway: BCL2 (BCL2) → Cytochrome C (CYCS) (translocation, inhibits) Gross et al., J Biol Chem 1999*
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: BCL2 — CYCS (in vivo) Chaloupka et al., FEBS Lett 1999*
• IRef Ophid Interaction: BCL2 — CYCS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Cosulich et al., Curr Biol 1999 : Cytochrome c release was accelerated by active caspase-3 and this positive feedback was negatively regulated by Bcl-2
Single et al., Exp Cell Res 2001 (Necrosis) : Cytochrome c release, normally preceding STS induced necrosis, was also inhibited by Bcl-2
MacLaren et al., Oncogene 2000 : Cytochrome C was released into the cytosol of apoptotic v-Jun expressing cells, and this release was inhibited by Bcl-2 , suggesting an important role for mitochondrial dysfunction in v-Jun induced apoptosis