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MAPK1 — RASSF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK1 → RASSF1 (increases, RASSF1 Activity) Thaler et al., Cancer Res 2009*
  Evidence: After stimulation with the mitogen phorbol 12-myristate 13- acetate (PMA) or serum, conditionally expressed RASSF1A specifically enhanced the activating phosphorylation of ERK, but not of p38 kinase or c-Jun NH2 kinase (Fig. 5A).
• OpenBEL Selventa BEL large corpus: MAPK1 → RASSF1 (increases) Thaler et al., Cancer Res 2009*
  Evidence: After stimulation with the mitogen phorbol 12-myristate 13- acetate (PMA) or serum, conditionally expressed RASSF1A specifically enhanced the activating phosphorylation of ERK, but not of p38 kinase or c-Jun NH2 kinase (Fig. 5A).
• OpenBEL Selventa BEL large corpus: MAPK1 → RASSF1 (increases) Thaler et al., Cancer Res 2009*
  Evidence: Serum stimulation of p53-deficient NCI-H1299 lung cancer cells conditionally expressing RASSF1A equally led to enhanced ERK phosphorylation and up-regulation of p21Cip1/Waf1 (Fig. 5B).

Text-mined interactions from Literome

Thaler et al., Cancer Res 2009 (MAP Kinase Signaling System) : Conditional RASSF1A affected mitogen activated protein kinase and protein kinase B/Akt signaling to up-regulate p21 ( Cip1/Waf1 ) and to facilitate its nuclear localization
Kumari et al., Exp Cell Res 2009 : Extracellular signal regulated kinase 2 ( ERK-2 ) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras associated tumor suppressor protein, RASSF2