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RAF1 — SPRY2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SPRY2 → RAF1 (increases)
  Evidence: Raf-expressing cells as a means of identifying potential candidate genes... Figures 4C - Transcriptional response to oncogenic raf. Figure 4D - change protein levels of some of the target genes
• WikiPathways Signaling Pathways in Glioblastoma: SPRY2 → ARAF/BRAF/RAF1 (mim-inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RAF1 — SPRY2 (physical association, affinity chromatography technology) Sasaki et al., Nat Cell Biol 2003*
• IRef Hprd Interaction: RAF1 — SPRY2 (in vitro) Sasaki et al., Nat Cell Biol 2003*

Text-mined interactions from Literome

Yang et al., Calcif Tissue Int 2006 : Taken together, these results indicate that Spry2 expression is an early response to stimulation by FGF1 in MC3T3-E1 cells and acts as a feedback inhibitor of FGF1 induced osteoblast responses, possibly through interaction with Raf1
Burgess et al., BMC developmental biology 2010 : Phospho-Erk1 and Erk2 levels were elevated in the lens but not in the cornea and Spry 1 and Spry 2 , negative regulators of Ras-Raf-Erk signaling, were upregulated more in the corneal than in the lens epithelial cells
Ahn et al., BMB Rep 2010 : Thus, our study provides the evidence that Spry2 does not directly regulate Raf-1 kinase activity, but instead acts as a scaffolding protein that assists interactions between Raf-1 kinase and its direct regulators