Gene interactions and pathways from curated databases and text-mining

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CXCL8 — SLPI

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CXCL8 → SLPI (decreases) Griffin et al., Cell Microbiol 2007*
    Evidence: Secretory leucoprotease inhibitor (SLPI)...It has been used in an aerosolized form in clinical trials for CF lung disease where it has been shown to decrease NE activity as well as IL-8 levels (McElvaney et al., 1992).