Evidence: Notch4 degradation is impaired in Fbw7-/- cells. In contrast, the expression of Notch1, Notch2 and Notch3 is comparable among different genotypes. The finding that Fbw7-/- embryos exhibit severe defects in vascular development is likely due to the upregulation of the transcriptional repressor Hey-1, a downstream effector of Notch signaling.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *