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SYT1 — TLR4
Text-mined interactions from Literome
Lee et al., J Biol Chem 2003
:
LY294002, dominant negative ( DN ) phosphatidylinositol 3-kinase (PI3K), or AKT ( DN ) inhibited NFkappaB activation,
p65 transactivation, and cyclooxygenase-2 (COX-2) expression
induced by lauric acid or constitutively active ( CA )
TLR4
Henning et al., J Immunol 2008
:
SP-A decreases the phosphorylation of IkappaBalpha, a key regulator of NF-kappaB activity, and nuclear translocation of
p65 which result in diminished TNF-alpha secretion in
response to
TLR ligands
Yoza et al., Cytokine 2011
(Sepsis) :
We further show
TLR dependent NF?B
p65 and histone H3 serine 10 phosphorylation binding at the promoter
Wu et al., Cell Physiol Biochem 2012
:
Ketamine ( 100 and 1000 µM ) reduced the expression of GFAP and the production of these proinflammatory cytokines,
inhibited the expression of
TLR4 and attenuated the phosphorylation of NF-?B
p65 in astrocytes challenged by LPS