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Nandate et al., Anesth Analg 2005
:
We investigated the
effect of
NAC on the expression of
CD11b and CD62L in endotoxin stimulated human whole blood ...
NAC ( > 10 mM ) significantly
inhibited the lipopolysaccharide (LPS) induced upregulation of
CD11b in a concentration dependent manner ... We also analyzed the
effect of
NAC on interleukin-8 (IL-8) induced expression of
CD11b in human whole blood ... IL-8 ( 10 ng/mL ) significantly upregulated the expression of
CD11b , and the IL-8 induced upregulation was significantly
attenuated by
NAC ( > 10 mM ) in a dose dependent manner ... We conclude that
NAC attenuates the increased expression of
CD11b in either LPS or IL-8 stimulated human whole blood
Elferink et al., Immunopharmacology 1998
:
In contrast with fMLP,
NAC did not
cause an upregulation of
CD11b expression of cells in suspension