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MAPK8 — NFKBIA
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Wang et al., Allergy 2005
:
IL-6 gene expression was assessed by reverse transcriptase-polymerase chain reaction ( RT-PCR ), and p38
MAPK activity and
inhibitor (I)kappaB-alpha induction were evaluated by Western blot
Calleros et al., Cell Signal 2006
(MAP Kinase Signaling System) :
Here, we found that inhibition of p38
MAPK with the specific inhibitor SB203580
blocked the increase in NFkappaB activity,
IkappaBalpha degradation and p65/NFkappaB translocation to the nucleus induced by cholesterol depletion
Tsuji et al., Int Immunopharmacol 2007
:
IL-1beta
induced phosphorylation of the
mitogen activated protein ( MAP ) kinases ,
IkappaBalpha , c-Jun and Akt
Adhikary et al., J Leukoc Biol 2008
(Corneal Diseases...) :
To determine the role of MAPKs in TLR- induced corneal inflammation, we stimulated human corneal epithelial (HCE) cells with TLR2 ligands, tripalmitoyl-S-glycero-Cys- ( Lys ) 4 ( Pam3Cys ) or inactivated Staphylococcus aureus, and examined the time course of expression of MAPKs and the
effect of
MAPK inhibition on
IkBalpha degradation and CXC chemokine production
Dragomir et al., Thromb Haemost 2008
:
The
MAPK inhibitors
blocked the phosphorylation of
IkBalpha and c-jun, indicating the role of MAPK in NF-kappaB and AP-1 activation in SMC under HG conditions
Schwenger et al., Mol Cell Biol 1998
:
Induction of p38
MAPK activation and
inhibition of TNF induced
IkappaB alpha degradation were demonstrated with pharmacologically achievable doses of NaSal
Lee et al., Proc Natl Acad Sci U S A 1998
:
We have previously shown that
mitogen activated protein kinase/ERK kinase kinase 1 ( MEKK1 ) can
induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight
IkappaB kinase complex in vitro