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PPARG — SREBF2

Pathways - manually collected, often from reviews:

• FastForward regulation: SREBF2 → PPARG (transcriptional regulation, unknown) Fajas et al., Mol Cell Biol 1999*
  Evidence: DNABINDING, PROMACTIVITY
• FastForward regulation: SREBF2 → PPARG (transcriptional regulation, increase) Fajas et al., Mol Cell Biol 1999*
  Evidence: DNABINDING, PROMACTIVITY

Text-mined interactions from Literome

Fajas et al., Mol Cell Biol 1999 : Both promoters contain a consensus E-box motif that mediates the regulation of the PPARgamma gene by ADD-1/SREBP-1 and SREBP-2
Kang et al., Endocrinology 2009 : In summary, our results demonstrate that curcumin inhibits srebp-2 expression in cultured HSCs by activating PPARgamma and reducing the SP-1 activity, leading to the repression of ldlr expression