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IFNG — SHH

Text-mined interactions from Literome

Wang et al., J Clin Invest 2003 (Central Nervous System Neoplasms...) : Moreover, a hitherto unknown role is indicated for the immune system in the pathogenesis of developmental disorders and tumorigenesis of the CNS via dysregulated Shh signaling mediated by IFN-gamma
Lin et al., J Neurosci 2004 (Cerebellar Ataxia...) : Thus, IFN-gamma expression in the perinatal period can induce SHH expression and medulloblastoma in the cerebellum by a STAT1 dependent mechanism, and its continued presence appears to promote a host response to the tumor
Sun et al., Brain Behav Immun 2010 : To determine the relationship between these distinct pathways, we have found that IFN-gamma induces a rapid Shh transcription in cultured primary granular neuron precursor ( GNP ) cells ... The transcriptional induction of Shh by IFN-gamma is resistant to protein synthesis inhibition