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IRF3 — TANK

Pathways - manually collected, often from reviews:

• Reactome Reaction: IRF3 → TANK (reaction) Fitzgerald et al., Nat Immunol 2003, Fitzgerald et al., J Exp Med 2003, Mori et al., J Biol Chem 2004, Hemmi et al., J Exp Med 2004, An et al., Immunity 2006, Panne et al., J Biol Chem 2007, Lin et al., Mol Cell Biol 1998
• Reactome Reaction: IRF3 → TANK (indirect_complex) Fitzgerald et al., J Exp Med 2003, Mori et al., J Biol Chem 2004, Hemmi et al., J Exp Med 2004, An et al., Immunity 2006, Lin et al., Mol Cell Biol 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TANK — IRF3 (physical association, affinity chromatography technology) Gatot et al., J Biol Chem 2007
• IRef Intact Interaction: Complex of 22 proteins (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011

Text-mined interactions from Literome

Gatot et al., J Biol Chem 2007 : Lipopolysaccharide mediated interferon regulatory factor activation involves TBK1-IKKepsilon dependent Lys ( 63 ) -linked polyubiquitination and phosphorylation of TANK/I-TRAF
Piao et al., J Leukoc Biol 2009 : Endotoxin tolerization suppressed LPS-inducible TLR4-TRIF and TRIF-TANK binding kinase (TBK)1 associations, induction of TBK1 kinase activity, activation of IFN regulatory factor (IRF)-3 , and expression of RANTES and IFN-beta
Liu et al., eLife 2013 : These results delineate the mechanism of MAVS signaling and reveal that TRAF2 , 5, and 6, which are normally associated with NF-?B activation, also play a crucial role in IRF3 activation in antiviral immune responses