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BAD — PRKAR1B
Pathways - manually collected, often from reviews:
-
BioCarta regulation of bad phosphorylation:
BAD/BCL-2 complex (BAD-BCL2)
→
PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B)
(modification, collaborate)
-
BioCarta regulation of bad phosphorylation:
BAD/BCL-XL complex (BAD-BCL2L1)
→
PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B)
(modification, collaborate)
-
KEGG Apoptosis:
PRKACA/PRKACB/PRKACG/PRKAR1A/PRKAR1B/PRKAR2A/PRKAR2B/PRKX
→
BAD
(protein-protein, inhibition)
Text-mined interactions from Literome
Affaitati et al., J Biol Chem 2003
:
AKAP121 induction stimulates
PKA dependent phosphorylation of the proapoptotic protein
BAD at Ser ( 155 ), inhibits release of cytochrome c from mitochondria, and protects cells from apoptosis
Cieslak et al., Mol Cells 2007
:
On the contrary, inhibition of
PKA or specifically PKCdelta
resulted in up-regulation of
BAD