Gene interactions and pathways from curated databases and text-mining

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INS — TSC1

Text-mined interactions from Literome

Garami et al., Mol Cell 2003 : Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
Harrington et al., J Cell Biol 2004 : Here, we show that TSC1-2 is required for insulin signaling to PI3K
Zhang et al., Free Radic Biol Med 2009 : Insulin signaling to mTORC1 is dependent upon phosphorylation of Akt/PKB and the inhibition of the tuberous sclerosis complex ( TSC1/2 ), thereby enhancing the phosphorylation of 4E-BP1 and S6K1