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BMPR2 — SMAD1

Pathways - manually collected, often from reviews:

• NCI Pathway Database BMP receptor signaling: BMP6/BMPR2/BMPR1A-1B complex (BMP6-BMPR2-BMPR1A_BMPR1B) → SMAD1 (SMAD1) (modification, activates) Ebisawa et al., J Cell Sci 1999
  Evidence: assay
• NCI Pathway Database ALK1 signaling events: BMP9/BMPR2/Endoglin/ALK1 (dimer) complex (GDF2-ACVRL1-ENG-BMPR2) → SMAD1-5-8-active (SMAD1/SMAD9/SMAD5) (modification, activates)
  Scharpfenecker et al., J Cell Sci 2007, Macías-Silva et al., J Biol Chem 1998, Chen et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database ALK1 signaling events: BMP9/BMPR2/Endoglin/ALK1 (dimer) complex (GDF2-ACVRL1-ENG-BMPR2) → SMAD1-5-8 (SMAD1/SMAD9/SMAD5) (modification, activates)
  Scharpfenecker et al., J Cell Sci 2007, Macías-Silva et al., J Biol Chem 1998, Chen et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database ALK2 signaling events: BMP7/BMPR2/ALK2 (dimer) complex (BMP7-ACVR1-BMPR2) → SMAD1-5-8 (SMAD1/SMAD9/SMAD5) (modification, activates)
  Macías-Silva et al., J Biol Chem 1998, Chen et al., J Biol Chem 1999
  Evidence: assay, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → ENDOFIN/SMAD1 complex (ZFYVE16-SMAD1) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → SMAD1 (SMAD1) (modification, collaborate) Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: ENDOFIN/SMAD1 complex (ZFYVE16-SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1) → SMAD1 (SMAD1) (modification, collaborate) Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ALK1 signaling events: BMP9/BMPR2/Endoglin/ALK1 (dimer)/CK2B complex (GDF2-ACVRL1-CSNK2B-ENG-BMPR2) → SMAD1-5-8 (SMAD1/SMAD9/SMAD5) (modification, activates)
  Lee et al., FASEB J 2009, Macías-Silva et al., J Biol Chem 1998
  Evidence: mutant phenotype
• Reactome Reaction: BMPR2 → SMAD1 (reaction) Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Lagna et al., Nature 1996, Kretzschmar et al., Genes Dev 1997
• Reactome Reaction: BMPR2 → SMAD1 (indirect_complex) Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
• WikiPathways Heart Development: BMPR2/BMPR1A → SMAD1 (activation)

Text-mined interactions from Literome

Yu et al., J Biol Chem 2008 : Although signaling via BMPRII or ActRIIa transiently activated SMAD1/5/8, only BMPRII signaling led to persistent SMAD1/5/8 activation and sustained increases in Id1 mRNA and protein expression
Graham et al., Prostate 2009 (Neoplasm Metastasis...) : Notably, the activation of BMPRII by BMP-2 is required for modulation of Smad activation by NF-kappaB in PC cells
Johnson et al., J Neuropathol Exp Neurol 2009 (Meningeal Neoplasms...) : In this study, frozen tissues from 26 World Health Organization Grades I to III meningiomas were analyzed by Western blot for BMP-2/4, BMPR IA, and BMPR II , and activation of downstream p-Smad1 , p38 mitogen activated protein kinase ( MAPK ), and p44/42 MAPK signaling molecules
Yang et al., Ann N Y Acad Sci 2010 (Bone Diseases, Developmental) : Thus, osteoblast targeted expression of dominant negative BMPRII leads to inhibited Smad1 phosphorylation, delayed skeletal development, and decreased bone formation in the adult mice ... This study provides an in vivo tool to study the role of BMPRII in BMP/Smad signaling and the regulation of this pathway by PTH and Wnts
Breen et al., PloS one 2013 (Neoplasm Invasiveness...) : In contrast BMPRII regulates Smad1 in a biphasic manner, promoting Smad1 signaling through its kinase domain but suppressing it through its cytoplasmic tail