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IGF1 — SHBG

Text-mined interactions from Literome

Kaaks et al., Gynecol Obstet Fertil 2001 (Breast Neoplasms) : Like insulin, IGF-I also inhibits the hepatic synthesis of SHBG , whereas both hormones stimulate the ovarian synthesis of sex steroids
Kaaks et al., Proc Nutr Soc 2001 (Neoplasms) : Furthermore, both insulin and IGF-I stimulate the synthesis of sex steroids, and inhibit the synthesis of sex hormone binding globulin ( SFIBG ), a binding protein that regulates the bioavailability of circulating sex steroids to tissues
Kalme et al., J Steroid Biochem Mol Biol 2003 : IGF-I and IGF-II also inhibited the IGFBP-1 and SHBG levels
Arcidiacono et al., Exp Diabetes Res 2012 (Diabetes Mellitus, Type 2...) : Insulin and IGF-I inhibit the hepatic synthesis of sex-hormone binding globulin (SHBG) , whereas both hormones stimulate the ovarian synthesis of sex steroids, whose effects, in breast epithelium and endometrium, can promote cellular proliferation and inhibit apoptosis
Garofalo et al., Mol Cell Biol 1989 : This protein was phosphorylated in response to IGF-1 and was not directly recognized by AbP4 or AbP5
Grunstein et al., J Clin Endocrinol Metab 1989 (Sleep Apnea Syndromes) : In the longitudinal study plasma IGF-I , total testosterone, and SHBG , but not free testosterone, significantly increased after 3 months of nasal continuous positive airways pressure treatment
von Schoultz et al., J Steroid Biochem 1989 (Liver Diseases) : The authors suggest that SHBG is regulated primarily by growth hormone, somatomedin-C and possibly other growth factors
Rudd et al., Acta Endocrinol Suppl (Copenh) 1986 : It was postulated that IGF-1 and free testosterone may regulate SHBG synthesis
Crave et al., J Clin Endocrinol Metab 1995 (Hepatoblastoma...) : The effects of insulin-like growth factor I (IGF-I) and insulin on CBG and SHBG synthesis by a clone of human hepatoblastoma derived ( Hep G2 ) cell lines were therefore investigated ... These results demonstrate that IGF-I reduces CBG and SHBG production by Hep G2 cells by decreasing mRNA steady state levels
Vermeulen et al., J Clin Endocrinol Metab 1996 (Obesity) : Considering that after weight loss, GH and IGF-I levels remained lower than those in the nonobese controls, that adult men with isolated GH deficiency presented with higher SHBG levels than normal controls, which decreased to normal levels during GH substitution, and that elderly men have elevated SHBG levels notwithstanding high insulin levels, we suggest that the low GH and/or IGF-I levels might play a role in the elevated SHBG levels observed in both elderly males and obese men after a weight reducing diet
Pugeat et al., Horm Res 1996 (Cardiovascular Diseases...) : Because of the inhibitory effect of both insulin and insulin-like growth factor-1 on SHBG secretion by Hep G2 cells in vitro, it has been proposed that SHBG levels could be a marker of insulin resistance and/or hyperinsulinism in humans
McCarty et al., Med Hypotheses 1997 (Arteriosclerosis...) : Since IGF-1 suppresses hepatic synthesis of sex hormone binding globulin (SHBG), down-regulation of IGF activity will increase SHBG levels and thus diminish the availability of free sex hormones -- an effect that should further decrease cancer risk in sex hormone-responsive tissues
Lecomte et al., Eur J Endocrinol 1998 : Multiple regression analysis was performed to define the role of age, insulin and IGF-I in the increase in SHBG ... In men, both age and IGF-I contributed to the SHBG increase